Many ways to die, one way to arrive: how selection acts through pregnancy.

Many ways to die, one way to arrive: how selection acts through pregnancy.
Trends Genet. 2013 Apr 5;
Authors: Brown EA, Ruvolo M, Sabeti PC
Abstract
When considering selective forces shaping human evolution, the importance of pregnancy to fitness should not be underestimated. Although specific mortality factors may only impact upon a fraction of the population, birth is a funnel through which all individuals must pass. Human pregnancy places exceptional energetic, physical, and immunological demands on the mother to accommodate the needs of the fetus, making the woman more vulnerable during this time-period. Here, we examine how metabolic imbalances, infectious diseases, oxygen deficiency, and nutrient levels in pregnancy can exert selective pressures on women and their unborn offspring. Numerous candidate genes under selection are being revealed by next-generation sequencing, providing the opportunity to study further the relationship between selection and pregnancy. This relationship is important to consider to gain insight into recent human adaptations to unique diets and environments worldwide.
PMID: 23566676 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - April 5, 2013 Category: Genetics & Stem Cells Authors: Brown EA, Ruvolo M, Sabeti PC Tags: Trends Genet Source Type: research