Integrating Fluorinated Polymer and Manganese ‐Layered Double Hydroxide Nanoparticles as pH‐activated 19F MRI Agents for Specific and Sensitive Detection of Breast Cancer

In this study, a novel hybrid19F MRI agent for pH ‐sensitive detection of breast cancer tissues is reported, a composite system designed by conjugating a perfluoropolyether onto the surface of manganese‐incorporated layered double hydroxide (Mn‐LDH@PFPE) nanoparticles. The19F NMR/MRI signals from aqueous solutions of Mn ‐LDH@PFPE nanoparticles are quenched at pH 7.4, but “turned on” following a reduction in pH to below 6.5. This is due to partial dissolution of Mn2+ from the Mn ‐LDH nanoparticles and subsequent reduction in the effect of paramagnetic relaxation. Significantly, in vivo experiments reveal that an intense19F MR signal can be detected only in the breast tumor tissue after intravenous injection of Mn ‐LDH@PFPE nanoparticles due to such a specific activation. Thus pH‐activated Mn‐LDH@PFPE nanoparticles are a potential “smart”19F MRI agent for precise and specific detection of cancer diseases.
Source: Small - Category: Nanotechnology Authors: Tags: Communication Source Type: research