Enhanced Expression of PD-L1 on Microglia After Surgical Brain Injury Exerts Self-Protection from Inflammation and Promotes Neurological Repair.

This study aimed to evaluate the expression and the role of PD-L1 in a mouse model of SBI induced inflammation and to further study the potential therapeutic effects of PD-L1 on SBI. Here we showed that PD-L1 expression was markedly elevated in the surrounding peri-resection brain tissue post-SBI in vivo. PD-L1 was up-regulated through ERK signal pathway in LPS-treated BV-2 cells in vitro. Furthermore, blockade of the PD-L1 checkpoint using PD-L1 antibody significantly enhanced brain edema, exacerbated apoptosis and increased neurodeficits post-SBI. Moreover, activated PD-1/PD-L1 with PD-L1 protein significantly attenuated the inflammation responses and brain edema post-SBI. These results suggest that enhanced expression of PD-L1 post-SBI exerts self-protection from inflammation and promotes neurological repair. PD-L1 signal may have therapeutic potential for neurodegenerative disorders. PMID: 31482256 [PubMed - as supplied by publisher]
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research

Related Links:

Publication date: 20 September 2019Source: Journal of Molecular Biology, Volume 431, Issue 20Author(s): Ludovic SauguetAbstractDNA and RNA polymerases (DNAP and RNAP) play central roles in genome replication, maintenance and repair, as well as in the expression of genes through their transcription. Multisubunit RNAPs carry out transcription and are represented, without exception, in all cellular life forms as well as in nucleo-cytoplasmic DNA viruses. Since their discovery, multisubunit RNAPs have been the focus of intense structural and functional studies revealing that they all share a well-conserved active-site region c...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
This study aimed to analyze the early and mid-term outcomes of aortic valve replacement with bovine pericardium in the treatment of aortic valve regurgitation.From January 2015 to March 2018, 36 patients (19 men; mean ± standard deviation [SD] age, 46.70 ± 16.60 years) underwent aortic valve replacement with bovine pericardium. The bovine pericardium was intraoperatively measured and shaped using an Ozaki template, according to the shape and size of the individual patient's aortic valve leaflets. Additional procedures were performed, including ventricular septal defect repair in 5 cases, mitral valve reconstr...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print.
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - Category: Surgery Authors: Source Type: research
Conditions:   Pain, Postoperative;   Palate; Wound;   Cicatrization Interventions:   Device: Tilapia skin;   Device: Platelet-Rich Fibrin;   Device: Hawley Retainer;   Device: Surgical Wound Dressing Sponsor:   University of Sao Paulo Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Post-op Complication Interventions:   Procedure: Crura dissection;   Procedure: Sleeve gastrectomy;   Procedure: Hiatal hernia repair Sponsor:   University of Miami Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cardiac Surgery Intervention:   Behavioral: Prehabilitation Sponsor:   Guy's and St Thomas' NHS Foundation Trust Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Birth Asphyxia Intervention:   Drug: Sildenafil Citrate Sponsor:   Pia Wintermark Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Periodontal Diseases Intervention:   Device: MIST (minimally invasive surgical therapy) Sponsors:   McGuire Institute;   Biolase Inc Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: December 2019Source: Journal of Vascular and Interventional Radiology, Volume 30, Issue 12Author(s): Ali Alsafi, Michael P. Jenkins, Mohamad S. Hamady
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: Available online 19 November 2019Source: The Journal of Foot and Ankle SurgeryAuthor(s): Kristin B. Kindred, Anthony S. Rusher, Andrew M. Baker, Corey N. Groh, Brett R. FinkAbstractPlantar plate tears are a common cause of forefoot pain and digital deformity. Repair of the plantar plate has been described from both a dorsal and plantar approach, each with its own benefits and drawbacks. Many of the approaches use costly devices. Our innovative repair method uses low-cost materials available in most operating room settings. We undertook a retrospective case series study to evaluate outcomes in patients who...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
More News: Brain | Gastroschisis Repair | Neurology | Neuroscience | Study