Lowbury Lecture 2018. Chlorhexidine-Based Decolonization to Reduce Healthcare-Associated Infections and Multidrug-Resistant Organisms (MDROs): Who, What, Where, When, and Why?

Publication date: Available online 5 September 2019Source: Journal of Hospital InfectionAuthor(s): Susan S. HuangSummaryBody surface decolonization with chlorhexidine bathing and nasal mupirocin has become a simple solution for prevention of healthcare-associated infections. The clinical trial evidence for this practice will be reviewed to understand who benefits from this practice, for what reasons, and at what times. The method of bathing and nasal decolonization will also be discussed as proper application is needed for maximal effectiveness. Finally, the conflict between current effectiveness and future potential for fueling resistance is considered.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research

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Abstract Multidrug resistance in M. tb has become a huge global problem due to drug resistance. Hence, the treatment remains a challenge, even though short term chemotherapy is available. Therefore, it is of interest to identify novel drug targets in M.tb through gene expression profiling complimented by a subtractive proteome model. WhiB6 is a transcriptional regulator protein and a known drug resistant marker that is critical in the secretion dependent regulation of ESX-1, which is specialized for the deployment of host membrane-targeting proteins. The WhiB6 protein structure was modelled ab initio and was docke...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
In this study, a series of new C–C terminals and C–N terminals dimer peptides were designed and synthesized by intermolecular dimerization of the partial d-amino acid substitution analogues of Anoplin, and the effects of different dimerization positions on biological activity were researched. The antimicrobial activity and stability of the new C–C terminals and C–N terminals dimer peptides were significantly improved compared with their parent peptide Anoplin. They displayed no obvious hemolytic activity and lower cytotoxicity, with a higher therapeutic index. Furthermore, the new dimer peptides not...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 13 November 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Lebogang Kenaope, Hannetjie Ferreira, Faheem Seedat, Kennedy Otwombe, Neil A. Martinson, Ebrahim VariavaAbstractSettingTshepong Hospital multidrug resistant (MDR) unit between April 2011 and February 2014.ObjectiveRifampicin resistant (RR) tuberculosis (TB) on X-pert MTB/Rif is assumed a surrogate for MDR TB. Following a RR result, a second specimen is taken for confirmatory culture and drug susceptibility testing (DST). We compare the initial diagnostic X-pert MTB/RIF result to the confirmatory DST in a high HIV...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
In this study, professionals were observed during patient care under empirical contact precautions. A total of 243 observations were performed in which 39.5% complied with all measures. The positivity rate of surveillance cultures was 38.36%, and adherence to the measures in patients with colonization was 43.1%.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
ConclusionsResistant MTB isolates in Algeria harbour resistance genotypes similar to other countries, but some rare patterns may result from selection and transmission processes inherent to the country.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionCirculating MDR A. baumannii exhibit genetic heterogeneity with variations in the structure and content of genomic A. baumannii resistance islands and encode multiple putative ARGs. This report represents the first clonal subtype information and genomic characterization of MDR A. baumannii in the country of Georgia and may inform future epidemiological investigations.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
AbstractThe increasing prevalence of multidrug-resistant strains ofMycobacterium tuberculosis (Mtb), the pathogen of human tuberculosis (TB), serves as a strong incentive for the discovery and development of new agents for the treatment of this plight. In search for such drugs, we investigated a series of benzyltriazole derivatives. We herein report the design, synthesis and biological activity of disubstituted benzyltriazoles against the human virulent H37Rv strain ofMtb as well as the toxicity on human embryonic kidney (HEK-293) cells. The derivative21 featuring trifluoromethyl substituent inpara position on the phenyl r...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
ConclusionsTherapeutic drug monitoring-guided meropenem may be a sound new therapeutic option in eradicating multidrug resistant Acinetobacter and offer a novel therapeutic option in the field of personalized medicine.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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