A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes

ConclusionPatient-specific hiPSC-CMs are able to recapitulate single-cell phenotype features of BrS withSCN10A mutations and may provide novel opportunities to further elucidate the cellular disease mechanism.

Source: Europace - May 18, 2019 Category: Cardiology Source Type: research