A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes
ConclusionPatient-specific hiPSC-CMs are able to recapitulate single-cell phenotype features of BrS withSCN10A mutations and may provide novel opportunities to further elucidate the cellular disease mechanism.
Series Type : Genome binding/occupancy profiling by high throughput sequencing ; Other ; Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
Discussion Just under 40% of people are eligible to be a blood donor. Up to 6.5% of a population are actual donors. “Blood donors are healthy volunteers who give either whole blood or blood components by apheresis including platelets, plasma, red blood cells, peripheral blood stem cells and leucocytes or a combination of blood components. They represent a large, healthy population exposing themselves voluntarily for altruistic, sometimes financial motives to potential complications and risks.” Blood banking systems world-wide are responsible for caring for individual donors health as well as maintaining a robus...
Publication date: Available online 14 December 2019Source: Chemico-Biological InteractionsAuthor(s): Ryan N. Serio, Lorraine J. GudasAbstractEthanol (EtOH) is a recreationally ingested compound that is both teratogenic and carcinogenic in humans. Because of its abundant consumption worldwide and the vital role of stem cells in the formation of birth defects and cancers, delineating the effects of EtOH on stem cell function is currently an active and urgent pursuit of scientific investigation to explicate some of the mechanisms contributing to EtOH toxicity. Stem cells represent a primordial, undifferentiated phase of devel...
CONCLUSIONS: The use of this novel cartilage restoration surgical technique provides excellent clinical, functional, and MRI-based outcomes in young, active individuals with full-thickness cartilage or osteochondral defects. LEVEL OF EVIDENCE: Level IV-Therapeutic case series. PMID: 31835970 [PubMed - in process]
ConclusionsOral complications in HSCT survivors are common and may include GVHD, dry mouth, and taste changes. All patients must be screened prior to HSCT and followed up by a dentist periodically to assess the oral health status and modify treatment, if needed.
ConclusionsThis baseline report reveals variations in dental diseases, oral hygiene practices, and dental treatments rendered before HSCT among different study centers. Establishment of an international standard of care for dental treatment before HSCT is needed. Prospective OraStem study data will increase the understanding of risk factors related to oral complications during HSCT.
Publication date: January 2020Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 1Author(s): LEONARDO AMARAL DOS REIS, RENATA LUCENA MARKMAN, LIANA PRETTO WEBBER, PABLO AGUSTIN VARGAS, JACKS JORGE, CRISTIANE HELENA SQUARIZE, ROGERIO CASTILHOMucoepidermoid carcinomas (MEC) are the most common malignancy of the salivary glands. Dysfunctional clock signaling is observed in a variety of pathologic conditions. Members of the clock gene family are upregulated in tumor cells. We explored the role of the mTOR signaling pathway, commonly found upregulated in tumors including in MEC, oral squam...
Conclusions: The 2 OSCC cell lines presented distinct patterns of cancer stem cells surface markers. Further experiments will be needed to better characterize the CSCs populations present in SCC9 and SCC9 ZsGreen LN1 cell lines. (FAPESP 14/20832-3).
We report 2 cases of oral squamous cell carcinoma in male patients with FA who underwent hematopoietic stem cell transplantation. Both patients presented with oral lichenoid lesions, compatible with chronic graft vs host disease. In the first case, a 16-year-old patient presented with an extensive infiltrative and necrotic lesion on the border of the tongue.
Fanconi Anemia (FA) is a rare autosomal recessive genetic disorder that can cause bone marrow failure and increased risk for malignancies. Hematopoietic stem cell transplantation (HSCT) in patients with FA also increases the risk of tumors. The following reported case is of a male patient, diagnosed with AF, with a history of HSCT at 4 years of age. At 14 years old, he presented with a painless ulcerated lesion, irregular borders, 3 cm in size, on the right lateral border of the tongue with a 20-day course, associated with a submandibular lymphadenopathy.