Distribution of transplantation-associated thrombotic microangiopathy (TA-TMA) and comparison between renal TA-TMA and intestinal TA-TMA: autopsy study

Thrombotic microangiopathy (TMA) is a syndrome caused by small vessel endothelial injury and clinically characterized by microangiopathic hemolytic anemia, elevated serum lactate dehydrogenase level, thrombocytopenia, and multiorgan injury [1]. Multiple factors can be the cause of a primary TMA [1]. ADAMTS13 deficiency-mediated TMA or Shiga toxin-mediated TMA are representative, and they have been familiarly called the thrombotic thrombocytopenic purpura (TTP) and Shiga toxin-related hemolytic uremic syndrome (ST-HUS), respectively [2,3].

Source: Biology of Blood and Marrow Transplantation - September 2, 2019 Category: Hematology Authors: Rin Yamada, Tetsuo Nemoto, Kazuteru Ohashi, Akiko Tonooka, Shin-ichiro Horiguchi, Toru Motoi, Tsunekazu Hishima Source Type: research