510 Understanding the roles of AKT1 loss and AKT2 activation during SCC progression

Cutaneous Squamous Cell Carcinoma (cSCC) represents about 20% of all non-melanoma skin cancers, with a dramatic increase in incidence in immunosuppressed patients. Since metastases of this disease are associated with a poor prognosis, there is interest in identifying new biomarkers of SCC metastasis as this could indicate new therapeutic targets. One potential candidate is the serine/threonine kinase AKT. AKT exists in two isoforms in the skin- AKT1 and AKT2- which perform different functions during skin homeostasis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research