Subcortical amyloid relates to cortical morphology in cognitively normal individuals

ConclusionsIn cognitively normal individuals, subcortical A β is associated with cortical volume, and this effect was driven by surface area with or without thickness. Aβ-associated cortical changes were found in the default mode network and affected cognitive performance. Our findings demonstrate the importance of studying subcortical Aβ and cortical sur face area in normal ageing.

http://link.springer.com/10.1007/s00259-019-04446-w

Source: European Journal of Nuclear Medicine and Molecular Imaging - August 31, 2019 Category: Nuclear Medicine Source Type: research