Transplantation of Human Umbilical Cord Blood-Derived Cellular Fraction Improves LV Function and Remodeling after Myocardial Ischemia/Reperfusion.

CONCLUSIONS: Transplantation of hUCB-derived CD45- Lin- nonhematopoietic cellular subfraction after a reperfused MI in nonimmunosuppressed rats ameliorates LV dysfunction and improves remodeling via favorable paracrine modulation of molecular pathways. These findings with human cells in a clinically relevant model of myocardial ischemia/reperfusion in immunocompetent animals may have significant translational implications.
PMID: 31462157 [PubMed - as supplied by publisher]

Source: Circulation Research - August 28, 2019 Category: Cardiology Authors: Zhao L, Cheng G, Choksi K, Samanta A, Girgis M, Soder RP, Vincent RJ, Wulser M, De Ruyter M, McEnulty P, Hauptman J, Yang Y, Weiner CP, Dawn B Tags: Circ Res Source Type: research