Comparison of high doses of total body irradiation in myeloablative conditioning prior to hematopoietic cell transplantation

Relapse of the underlying disease is the most frequent cause of treatment failure after allogeneic HCT for hematologic malignancies [1]. Non-relapse mortality (NRM) accounts for the bulk of the remainder of deaths (20-30%) [2 –5]. One of the strategies to reduce relapse risk is to intensify the pre-transplant conditioning regimen. Several studies have demonstrated that increasing the intensity of the conditioning regimen can reduce relapse risk [6–9]. Indeed, a prospective randomized trial of myeloablative (MAC) vers us reduced intensity conditioning (RIC) for adults with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) in first remission confirmed that greater conditioning intensity resulted in significantly lower relapse risk and improved relapse-free survival [10].

Source: Biology of Blood and Marrow Transplantation - August 28, 2019 Category: Hematology Authors: Mitchell Sabloff, Saurabh Chhabra, Tao Wang, Caitrin Fretham, Natasha Kekre, Allistair Abraham, Kehinde Adekola, Jeffery J Auletta, Christopher Barker, Amer M. Beitinjaneh, Christopher Bredeson, Jean-Yves Cahn, Miguel Angel Diaz, Cesar Freytes, Robert Pet Source Type: research