Promising approaches of small interfering RNAs (siRNAs) mediated cancer gene therapy.

Promising approaches of small interfering RNAs (siRNAs) mediated cancer gene therapy. Gene. 2019 Aug 24;:144071 Authors: Senapati D, Patra BC, Kar A, Chini DS, Ghosh S, Patra S, Bhattacharya M Abstract RNA interference (RNAi) has extensive potential to revolutionize every aspect of clinical application in biomedical research. One of the promising tools is the Small interfering RNA (siRNA) molecules within a cellular component. Principally, siRNA mediated innovative advances are increasing rapidly in support of cancer diagnosis and therapeutic purposes. Conversely, it has some delivery challenges to the site of action within the cells of a target organ, due to the progress of nucleic acids engineering and advance material science research contributing to the exceptional organ-specific targeted therapy. This siRNA based therapeutic technique definitely favors a unique and effective prospect to cancer patients. Herein, the significant drive also takes to review and summarize the major organ specific targets of diverse siRNAs based gene silencing mechanism. This machinery promisingly served as the inhibitor components for cancer development in the human model. Furthermore, the focus is also given to current applications on siRNA based quantifiable therapy leading to the silencing of cancer related gene expression in a sequence dependent and selective manner for cancer treatment. That might be a potent tool against the traditional chemoth...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research