Discovery of Aberrant Alteration of Genome in Colorectal Cancer by Exome Sequencing.

CONCLUSIONS: We frequently found novel genes ZNF717, ZNF493, CDR1, ARMC4 and SUMF2 and gains in 10q25.3, which may be functional mutation in CRC. The high-frequency private events such as SNVs confirm the highly heterogeneous mutations found in CRCs. The mutated genes sites in different patients may vary significantly, which may also be more challenging for clinical treatment.
PMID: 31445671 [PubMed - as supplied by publisher]

Source: The American Journal of the Medical Sciences - July 31, 2019 Category: General Medicine Authors: Liang Y, Jiang L, Zhong X, Hochwald SN, Wang Y, Huang L, Nie Q, Huang H, Xu JF Tags: Am J Med Sci Source Type: research