1007 - metabolic restoration of the aged hematopoietic stem cell microenvironment

Blood production depends relies on haematopoietic stem cells (HSC) regenerating and differentiating into all mature cell lineages. With age, HSC lose regenerative capacity and become metabolically more active, resulting in an expanded HSC pool coinciding with skewed lineage differentiation. Ultimately this can lead to anaemia, marrow failure or leukaemia. A contributing factor to impaired hematopoiesis with age is the loss of key nutrients in the microenvironment involved in the maintenance of HSC metabolic stability.
Source: Experimental Hematology - Category: Hematology Authors: Source Type: research