EP News: Allied Professionals

In this paper by DeWitt et  al (J Am Coll Cardiol 2019;74:346–358, PMID 31319917), the authors describe the variable phenotype (clinical characteristics) in a group of children diagnosed with arrhythmogenic cardiomyopathy (AC). In this single-center retrospective study, the authors searched their database for all patients
Source: Heart Rhythm - Category: Cardiology Authors: Tags: EP News Source Type: research

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RESUMO A sepse persiste como importante sobrecarga à saúde pública nos Estados Unidos e em todo o mundo. Com o crescente uso de tecnologias laboratoriais, tem se renovado o interesse na utilização de biomarcadores na sepse, para auxiliar em um processo mais preciso e direcionado para tomadas de decisão. Os peptídeos natriuréticos vem sendo c ada vez mais reconhecidos por seu papel que vai além da insuficiência cardíaca. Estes peptídeos estão comumente elevados em pacientes críticos que apresentam condições de disf...
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Source Type: research
AbstractHeart failure is one of the major cardiovascular complications in patients with type 2 diabetes mellitus (T2DM) and increases the risk of morbidity and mortality. Although active management for heart failure is needed in patients with T2DM, traditional treatment and some new class of antihyperglycemic drugs, such as glucagon-like peptide-1 receptor agonists or dipeptidyl peptidase-4 inhibitors, could not reduce the risk of heart failure. Recent major trials demonstrated sodium –glucose co-transporter-2 (SGLT2) inhibitors improve prognosis of T2DM patients through prevention of heart failure. Both heart failur...
Source: Journal of Echocardiography - Category: Cardiology Source Type: research
AbstractA 45 ‐year‐old male presented in decompensated heart failure from nonischemic cardiomyopathy and was implanted with a right transaxillary intra‐aortic balloon pump. He was listed for heart transplantation but after 9 days, he developed abdominal pain with evidence of embolization on computed tomogr aphy scan despite a well‐positioned balloon pump. He underwent concomitant abdominal exploration with small bowel resection and durable left ventricular assist device implantation. He recovered well and was discharged home. This case highlights the challenges of decision‐making in the current er a where intra...
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
PMID: 31609654 [PubMed - in process]
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
Left ventricular noncompaction (LVNC) is a form of cardiomyopathy characterized by deep trabeculations within the left ventricle.1,2 It has been associated with a high risk of cardiac events in children including cardiac dysfunction, arrhythmias, and sudden death.3,4 One association that has been reported with LVNC is Wolff-Parkinson-White (WPW), with previous estimated incidences of 5-17%.4 –8 However, the overall prevalence, characteristics, and outcomes of this group remain poorly understood.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Brief Report Source Type: research
Abstract OBJECTIVE: The aim of this study was to examine the local myocardial segments in hypertrophic cardiomyopathy (HCM) by MRI T1 and T2 mapping, and to investigate how tissue remodeling correlates with structural and functional remodeling in HCM. METHODS: 47 patients with HCM and 19 healthy volunteers were enrolled in this study. All subjects underwent cardiac MRI at 3.0 T. Native T1 and T2 values, end-diastolic wall thickness (EDTH), and percentage of systolic wall thickening (PSWT) were assessed in the left ventricular segments according to the American Heart Association model. Myocardial segments were...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
In this study, we explored the effect of Gfi-1 on lipopolysaccharide (LPS)-induced inflammatory responses and apoptosis in H9c2 cells. We found that LPS induced the increased expression of TNF- α and IL-6 in the LPS group. After transfection of the Gfi-1 overexpression plasmid, the expression of TNF-α and IL-6 decreased significantly in the LPS + Gfi-1 group. Gfi-1 clearly blocked LPS-induced NF-κB, TNF-α, TNFR1, cleaved-caspase-3 and cleaved-caspase-8 expression and increased Gfi-1 an d Bcl-xL expression in H9c2 cells. Similarly, compared with the LPS group, Gfi-1 significantly decreased the expres...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Complex interactions between splanchnic and systemic hemodynamic changes are characteristic features of advanced cirrhosis [1]. Splanchnic and systemic vasodilation associated with decreased systemic vascular resistance (SVR) and increased cardiac output result in a hyperkinetic state [2 –4]. However, the imbalance between systemic and splanchnic circulation is associated with a state of effective hypovolemia. Besides hyperkinetic state and effective hypovolemia, the so-called cirrhotic cardiomyopathy has been described several years ago [5,6].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Abstract Diabetic retinopathy (DR) is one of the diabetic complications associated with hyperglycemia-mediated oxidative stress. Activin receptor-like kinase 7 (ALK7) has been proven to be a potential therapeutic approach for diabetic cardiomyopathy, which is another diabetic complication. However, the role of ALK7 in DR remains unclear. In the current study, ALK7 was found to be up-regulated in clinical samples from DR patients and high glucose (HG)-induced human retinal pigment epithelial cells (ARPE-19). In vitro studies demonstrated that knockdown of ALK7 in ARPE-19 cells through transfection with siRNA-ALK7 (...
Source: Clinical and Experimental Pharmacology and Physiology - Category: Drugs & Pharmacology Authors: Tags: Clin Exp Pharmacol Physiol Source Type: research
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