Selenium nanoparticles as new strategy to potentiate γδ T cell anti-tumor cytotoxicity through upregulation of tubulin-α acetylation.

In conclusion, SeNPs could significantly potentiate anti-tumor cytotoxicity of Vγ9Vδ2 T cells, and both cytotoxicity related molecules and tubulin acetylation were involved in fine-tuning γδ T cell toxicity against cancer cells. Our present work demonstrated a new strategy for further enhancing anti-tumor cytotoxicity of human Vγ9Vδ2 T cells by using SeNPs-based nanotechnology, not gene modification, implicating SeNPs-based nanotechnology had a promising clinical perspective in the γδ T cell immunotherapy for malignant tumors.
PMID: 31442884 [PubMed - as supplied by publisher]

Source: Biomaterials - August 12, 2019 Category: Materials Science Authors: Hu Y, Liu T, Li J, Mai F, Li J, Chen Y, Jing Y, Dong X, Lin L, He J, Xu Y, Shan C, Hao J, Yin Z, Chen T, Wu Y Tags: Biomaterials Source Type: research