Acute resveratrol supplementation in coronary artery disease: towards patient stratification.

CONCLUSION: Acute high dose supplementation with RV improved FMD in patients after CABG surgery but impaired FMD in patients who underwent PCI. The revascularization method-related differential effects of RV may be due to its direct effects on endothelial-dependent dilator responses. Our findings have important implications for personalized treatment and stratification of older CAD patients. PMID: 31429599 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research

Related Links:

170Objectives: Dynamic myocardial PET study with 15O-H2O enables the quantification of regional myocardial perfusable tissue fraction (PTF). However, the left ventricular (LV) wall motion artifact decreases the accuracy of the value. Then, we performed electro-cardiogram (ECG) gated dynamic myocardial PET with 15O-H2O and developed the programs for accurate estimation of the PTF in the ischemic myocardial lesions after revascularization. Methods: Thirty patients (68±12 years old, male 28, female 2) with ischemic heart disease were employed. They all had percutaneous coronary intervention (PCI) or coronary artery byp...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science: Advances in Clinical Utility of Myocardial Blood Flow Quantification Source Type: research
259Objectives: To estimate myocardial flow reserve (MFR = stress myocardial blood flow (MBF) / rest MBF) in the ischemic myocardial lesion before and after revascularization with 15O-H2O PET, we developed a method to improve the detectability of MFR using electro-cardiogram (ECG)-gated dynamic myocardial PET with 15O-H2O, which would reduce the left ventricular (LV) wall motion artifact. Estimated MFR from the new method were compared with those from the conventional non-gated dynamic PET. Methods: Thirty patients with ischemic heart disease (68±12 years old, male28, female 2) underwent dynamic 15O-H2O PET during re...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiac and Cancer Imaging (Data Management, PIDS) Source Type: research
Background: The main goal of coronary revascularization is to restore myocardial perfusion in case of ischemia, causing coronary artery disease. Yet, little is known on the effect of revascularization on absolute myocardial blood flow (MBF). Therefore, the present prospective study assesses the impact of coronary revascularization on absolute MBF as measured by [15O]H2O positron emission tomography and fractional flow reserve (FFR) in patients with stable coronary artery disease. Methods and Results: Fifty-three patients (87% men, mean age 58.7±9.0 years) with suspected coronary artery disease were included prospec...
Source: Circulation: Cardiovascular Imaging - Category: Radiology Authors: Tags: Nuclear Cardiology and PET, Cardiovascular Surgery, Percutaneous Coronary Intervention, Revascularization Cardiovascular Imaging Source Type: research
This study evaluated angiographic success and in-hospital outcomes of percutaneous coronary intervention (PCI) with rotational atherectomy (RA) in patients with low left ventricular ejection fraction (LVEF). DESIGN: Between January 2010 and March 2014, 272 consecutive patients with heavily calcified lesions underwent elective PCI with RA. Of these, 33 patients had LVEF ≤35% (low LVEF group), whereas 237 patients had LVEF >35% (preserved LVEF group). The primary endpoint was angiographic success and in-hospital major adverse cardiac events (MACE). MACE included death from any cause, postprocedure ons...
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
CONCLUSIONS: The long-term outcome following myocardial revascularization, using the left internal mammary artery and the great saphenous vein as conduits, is favourable and improving. This is reflected by the 5-year survival of 89.9%, deviating minimally from the survival rate of the general Icelandic population, together with a freedom from major adverse cardiac and cerebrovascular events of 80.3%. PMID: 28805102 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
In conclusion, minimally invasive direct coronary artery bypass grafting combined with thoracoscopic wedge resection is an effective minimally invasive treatment for concurrent lung cancer and coronary artery disease. This technique eliminates the risk of perioperative bleeding and provides satisfactory mid-term follow-up results. PMID: 28194252 [PubMed - in process]
Source: Videosurgery and Other Miniinvasive Techniques - Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research
Conclusions Although CAC progression was independently, but modestly, associated with CVD outcomes, this relationship was no longer significant when including follow-up CAC in the model. These findings imply that if serial CAC scanning is performed, the latest scan should be used for risk assessment, and in this context, CAC progression provides no additional prognostic information.
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - Category: Radiology Authors: Tags: Original Research Source Type: research
We examined the red thrombi histopathologically. Hematoxylin and eosin staining revealed high-grade spindle cell sarcoma with variable degrees of atypia and nuclear polymorphism (Panel E). There were no specific findings in the Whole-body Positron Emission Tomography and Computed Tomography scan. To confirm the definitive diagnosis, she underwent coronary artery bypass surgery (saphenous vein graft to RCA) 4 months after PCI. During the surgery, two small solid masses were detected on the surface of the distal RCA. Intraoperative biopsy confirmed intimal sarcoma. Cryothermy coagulation was performed during the surgery, and...
Source: European Heart Journal - Category: Cardiology Source Type: research
This study determined the effect of optimal medical therapy (OMT), with or without percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), on long-term outcomes with respect to LVEF and number of diseased vessels, including proximal left anterior descending artery involvement.MethodsA patient-level pooled analysis was undertaken in 3 federally-funded trials. The primary endpoint was the composite of death, myocardial infarction (MI), or stroke, adjusted for trial and randomization strategy.ResultsAmong 5,034 subjects, 15% had LVEF  
Source: Journal of the American College of Cardiology: Cardiovascular Imaging - Category: Radiology Source Type: research
CONCLUSION: CCTA has high diagnostic and prognostic value in patients with high likelihood of coronary artery disease and could, in theory, be used to triage high risk patients. As many obstacles remain, including logistical and safety issues, our study does not support the use of CCTA as an additional diagnostic test before ICA in an all-comer NSTEMI population. PMID: 27366972 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
More News: Angioplasty | Antidoxidants | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Coronary Angioplasty | Coronary Artery Bypass Graft | Eyes | Heart | Percutaneous Coronary Intervention | PET Scan