An organic electrochemical transistor integrated with a molecularly selective isoporous membrane for amyloid-β detection

Publication date: 15 October 2019Source: Biosensors and Bioelectronics, Volume 143Author(s): Shofarul Wustoni, Shaofei Wang, Juan R. Alvarez, Tania C. Hidalgo, Suzana P. Nunes, Sahika InalAbstractAlzheimer's disease (AD) is a progressive neurodegenerative disease associated with severe memory loss and impaired cognitive skills. A common pathological change found in AD-affected brains is the accumulation of a peptide named amyloid-β (Aβ) that can form plaques. Aβ aggregates are visible to structural scanning tools; however, these bulky and expensive instruments are accessible to trained personnel in clinical settings only, thus hampering timely diagnosis of the disease, particularly in low-resource settings. In this work, we design an organic electrochemical transistor (OECT) for in vitro detection of Aβ aggregates in human serum. The OECT channel is integrated with a nanostructured isoporous membrane which has a strong affinity for Aβ aggregates. The detection mechanism relies on the membrane capturing Aβ aggregates larger than the size of its pores and thus blocking the penetration of electrolyte ions into the channel underneath. Combining the high transconductance of the OECT with the precise porosity and selectivity of the membrane, the device detects the presence of Aβ aggregates in human serum samples with excellent sensitivity. This is the first-time demonstration of a biofunctionalized, nanostructured, and isoporous membrane integrate...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research

Related Links:

Abstract Immune-mediated inflammation of the brain has been recognized for more than 50 years, although the initial descriptions were mainly thought to be secondary to an underlying neoplasm. Some of these paraneoplastic encephalitides express serum antibodies, but these were not thought to be pathogenic but instead have a T-cell-mediated pathophysiology. Over the last two decades, several pathogenic antibodies against neuronal surface antigens have been described in autoimmune encephalitis, which are amenable to immunotherapy. Several of these antibodies are directed against glutamate receptors (GluRs). NMDA...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
(University of Tsukuba) Hearing loss has a profound impact on older people, as it can lead to anxiety, restricted activity, and perhaps even cognitive decline and dementia. Research in Japan led by the University of Tsukuba examined associations of hearing loss with outdoor activity limitations, psychological distress, and memory loss in people aged 65 and over. All three conditions were significantly worse when there was hearing loss. The findings support early interventions such as use of hearing aids.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Use of hearing aids tied to better episodic memory scores in longitudinal study
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Neurology, ENT, Psychiatry, Geriatrics, Journal, Source Type: news
Marijuana consists of a mixture of dried plant leaves, flowers, and/or stems of the Cannabis Sativa plant. In addition, there is a resin-based version of marijuana that is called hash. Most people either smoke marijuana or vape it (warming it, but not cooking it), but it can also be ingested in oil form. The most common way to ingest marijuana is to roll it up and smoke it like you would a cigarette or cigar, or use a smoking tool like a pipe. Some users, however, consume weed by infusing foods (i.e., butter and cooking oil) or teas. What happens to your body when you ingest marijuana? THC (tetrahydrocannabinol) is the mos...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain Blogger Publishers Research Sexuality Substance Abuse Cannabis Climax Dopamine effects of marijuana erection Orgasm Pot Premature Ejaculation Sexual Desire Sexual Dysfunction THC types of sexual dysfunctions Weed Source Type: blogs
This study is the clearest demonstration in humans that sleep disruption leads to an increased risk of Alzheimer’s disease through an amyloid beta mechanism,” said senior author Randall Bateman, MD, the Charles F. and Joanne Knight Distinguished Professor of Neurology. “The study showed that it was due to overproduction of amyloid beta during sleep deprivation.”More than 5 million Americans are living with Alzheimer ’s, a disease characterized by gradual memory loss and cognitive decline.What is the Difference Between Alzheimer ’s and DementiaThis study indicatesthat sleeping poorly...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: health lack of sleep alzheimer's lack of sleep dementia poor sleep linked to alzheimer Source Type: blogs
Objective:The present study aims to determine the sensitivity and specificity of screening questions to detect HIV-associated neurocognitive disorders (HAND).Background:To improve detection of HAND, the European AIDS Clinical Society (EACS) recommends asking the three EACS screening questions (ESQ) relating to memory loss, mental slowing, and attention disorders.Design/Methods:In this prospective ongoing multicenter cohort study embedded within the Swiss HIV Cohort Study, 899 subjects older than 45 years were enrolled and asked the ESQ prior to undergo a thorough standardized neuropsychological assessment including mood sc...
Source: Neurology - Category: Neurology Authors: Tags: HIV, HTLV-I, PML, Other Viral Infections, and CJD Source Type: research
The recent announcement by Eli Lilly that a new drug intended to slow memory loss in people with Alzheimer's had failed a late-stage clinical trial felt like a punch in the gut. Look, I know that finding a treatment for dementia is a complex, Herculean task. But I was so sure that this time it was going to happen. And when it didn't, I knew the devastation that the thousands of people who volunteered for this clinical trial must have felt, as well as the dedicated Eli Lilly researchers and all those who'd devoted their time and energy to crushing this relentless killer. Despite this setback - because of it, really - I am...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
This study included 647 patients 80 to 106 years of age who had audiometric evaluations at an academic medical center (141 had multiple audiograms). The degree of hearing loss was compared across the following age brackets: 80 to 84 years, 85 to 89 years, 90 to 94 years, and 95 years and older. From an individual perspective, the rate of hearing decrease between 2 audiograms was compared with age. The researchers found that changes in hearing among age brackets were higher during the 10th decade of life than the 9th decade at all frequencies for all the patients (average age, 90 years). Correspondingly, the annual rate of ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We all grow old and all lose cognitive function, but different people of the same age exhibit quite a wide range of variation in losses and remaining capabilities. Most researchers are far more interested in investigating relative differences in natural aging, as this aids in the mapping of exactly how aging progresses, than they are interested in building treatments for aging, sad to say. So we see a lot of studies of this sort, generating a greater understanding that is both irrelevant and useless for the age of rejuvenation therapies to come. It won't meaningfully contribute to the production of treatments that can repa...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
More News: Amnesia | Biotechnology | Brain | HIV AIDS | Nanotechnology | Neurology | Organic | PET Scan