Obesity and Meniscal Transplant Failure: A Retrospective Cohort Study

In this study, a BMI ≥ 30 kg/m2 resulted in higher MAT failure rates. Nonobese patients had better knee functional results compared with obese individuals. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

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Publication date: Available online 20 September 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Ken Walder, Michael BerkAbstractActivated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and consequent mitochondrial aberrations are involved in the pathophysiology of psychiatric disorders including major depression, bipolar disorder and schizophrenia. They offer independent and shared contributions to pathways underpinning medical comorbidities including insulin resistance, metabolic syndrome, obesity and card...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
BACKGROUND: Two-thirds of Canadian adults and one-third of Canadian children and youth are overweight or obese. There is increased interest in identifying features of the built environment-such as walkability-that facilitate lifestyle habits associated wit...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Pedestrians and Bicycles Source Type: news
This study of 905 adolescents (age 13-17 yea...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
The aim of this study was to determine the risk of having significant depressive symptoms in subjects with obesity and type 2 diabetes mellitus through a meta-analysis. Our results showed that individuals with obesity and diabetes have an increased risk of...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Recent studies published in this journal and elsewhere (1,2) have shown promising data on the therapeutic potential of left gastric artery (LGA) embolization for the treatment of obesity and its associated comorbidities. Ischemia of the gastric fundus, which plays an important role in the hormonal regulation of appetite, is thought to be the primary mechanism underlying the effects of bariatric embolization (3). Therefore, a thorough understanding of gastric arterial anatomy, including variant anatomy, is important, as embolization of any accessory vessels supplying the gastric fundus may have potential benefit in optimizi...
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter Section Source Type: research
Publication date: Available online 20 September 2019Source: The Journal of Foot and Ankle SurgeryAuthor(s): Robert Anderson, Selene Parekh, Mary Jo Braid-Forbes, R. Grant SteenAbstractThe most common fracture in primary care is metatarsal fracture, but it is controversial whether to treat this fracture conservatively or surgically. We performed a cohort study to contrast metatarsal fractures that heal normally with fractures that show delayed healing. We analyzed 5% Medicare Standard Analytic Files, selecting all metatarsal fractures in 2011 to 2013, excluding patients with multiple fractures. Delayed healing was defined a...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print
Source: Journal of Pediatric Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Abstract Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease that is characterized by primary ciliary dysfunction (ciliopathy) and progresses to end-stage kidney disease (ESKD) during the second decade of life (juvenile and adolescent NPHP) or before the age of 3 years (infantile NPHP). Here we describe the case of an infant with NPHP who carries a homozygous mutation in SDCCAG8 (also called NPHP10 or BBS16) that encodes SDCCAG8 (serologically defined colon cancer antigen 8). SDCCAG8 is localized at the centrioles of both renal epithelial cells and retinal photoreceptor cells. A mutation in SDC...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
Abstract Computational drug repositioning, designed to identify new indications for existing drugs, significantly reduced the cost and time involved in drug development. Prediction of drug-disease associations is promising for drug repositioning. Recent years have witnessed an increasing number of machine learning-based methods for calculating drug repositioning. In this paper, a novel feature learning method based on Gaussian interaction profile kernel and autoencoder (GIPAE) is proposed for drug-disease association. In order to further reduce the computation cost, both batch normalization layer and the full-conn...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
jo EP Abstract Interleukin-6 (IL-6) is a unique cytokine that can play both pro- and anti-inflammatory roles depending on the anatomical site and conditions under which it has been induced. Specific neurons of the hypothalamus provide important signals to control food intake and energy expenditure. In individuals with obesity, a microglia-dependent inflammatory response damages the neural circuits responsible for maintaining whole-body energy homeostasis, resulting in a positive energy balance. However, little is known about the role of IL-6 in the regulation of hypothalamic microglia. In this systematic review, w...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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