Inherited alterations of TGF beta signaling components in Appalachian cervical cancers

ConclusionsThis study reports novel associations between common low-penetrance alleles in the TGFB signaling cascade and modified risk of cervical cancer in Appalachian women. Furthermore, our unexpected findings associating Appalachian identity andNQO1 rs1800566 suggests that the complex environmental exposures that contribute to Appalachian self-identity in Appalachian cervical cancer patients represent an emerging avenue of scientific exploration.

http://link.springer.com/10.1007/s10552-019-01221-y

Source: Cancer Causes and Control - August 20, 2019 Category: Cancer & Oncology Source Type: research