Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade [Immunology and Inflammation]

Immunotherapy using checkpoint-blocking antibodies against PD-1 has produced impressive results in a wide range of cancers. However, the response remains heterogeneous among patients. We used noninvasive immuno-positron emission tomography (PET), using 89Zr-labeled PEGylated single-domain antibody fragments (nanobodies or VHHs), to explore the dynamics and distribution of intratumoral CD8+ T cells...

Source: Proceedings of the National Academy of Sciences - August 19, 2019 Category: Science Authors: Mohammad Rashidian, Martin W. LaFleur, Vincent L. Verschoor, Anushka Dongre, Yun Zhang, Thao H. Nguyen, Stephen Kolifrath, Amir R. Aref, Christie J. Lau, Cloud P. Paweletz, Xia Bu, Gordon J. Freeman, M. Inmaculada Barrasa, Robert A. Weinberg, Arlene H. Sh Tags: PNAS Plus Source Type: research