Siphonaxanthin, a carotenoid from green algae, suppresses advanced glycation end product-induced inflammatory responses

AbstractAdvanced glycation end products (AGEs) induce inflammation and contribute to the pathogenesis of atherosclerosis. Although many studies have demonstrated the protective effects of carotenoids against atherosclerosis, the effects of carotenoids on AGE-induced inflammation have not been characterized. As such, we aimed to identify carotenoids that provided protection against AGE-elicited inflammation. AGE-stimulated RAW264 macrophages were first evaluated for NO generation. Among 17 carotenoids tested, only siphonaxanthin significantly suppressed it. Next, mRNA expression levels were measured in RAW264 macrophages and human umbilical vascular endothelial cells following siphonaxanthin and AGE treatment. Siphonaxanthin significantly suppressed AGE-induced mRNA expression of interleukin-6 and cellular adhesion molecules, which are known to be important for the pathogenesis of atherosclerosis. Siphonaxanthin also significantly suppressed endoplasmic reticulum (ER) stress marker genes. A reporter gene assay revealed that siphonaxanthin, as well as an ER stress inhibitor, significantly inhibited AGE-induced nuclear factor- κB (NF-κB) activation. Altogether, mitigation of ER stress and subsequent NF-κB activation is one of the molecular mechanisms by which siphonaxanthin suppressed AGE-elicited inflammation. Siphonaxanthin is a carotenoid commonly found in standard diets and is considered relatively safe for human c onsumption, and hence, dietary intake of s...
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research

Related Links:

Abstract OBJECTIVE: Using a feasibility analysis and matched subgroup analysis, this study investigated the implementation/safety/outcomes of a stroke recovery program (SRP) integrating modified cardiac rehabilitation for stroke survivors. DESIGN: This prospective cohort study of 783 stroke survivors were discharged from an inpatient rehabilitation facility to an outpatient setting; 136 SRP-participants completed a feasibility study and received the SRP including modified cardiac rehabilitation, 473 chose standard of care rehabilitation (nonparticipants), and a group (n = 174) were excluded. The feasibility s...
Source: Health Physics - Category: Physics Authors: Tags: Am J Phys Med Rehabil Source Type: research
Publication date: Available online 21 October 2019Source: Best Practice &Research Clinical AnaesthesiologyAuthor(s): Girish P. Joshi, Francis Bonnet
Source: Best Practice and Research Clinical Anaesthesiology - Category: Anesthesiology Source Type: research
ConclusionsThis case series demonstrates that the use of a high frequency jet ventilator for cardiac MRI was feasible, safe, providing good quality cardiac imaging and avoiding anesthesia personnel to be inside the hazardous environment of MRI room. Future studies are needed to confirm its safety and efficiency in pediatric patients.ResumoJustificativa e objetivosA ressonância magnética (RM) cardíaca é uma técnica utilizada na avaliação de crianças com cardiopatias congênitas. A anestesia geral garante imobilidade, especialmente em pacientes não cooperador...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
This article focuses on the functional features of positive-pressure ventilators, the modes of invasive and non-invasive mechanical ventilation, and the main ventilator settings. It also highlights the potential complications of mechanical ventilation, the basic principles of weaning, and the pathophysiological basis of patient-ventilator dyssynchrony.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
In conclusion, this review reported that IL-37 has a crucial role in reducing infection-associated inflammation and has a good impact on inflammation-induced pathology. However, tight regulation that achieved balance between effector immune responses that required for pathogen elimination and limited tissue damage that resulted from excessive inflammation should be existed in the potential IL-37 therapy to prevent clinical complications of a disease. PMID: 31633447 [PubMed - as supplied by publisher]
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
Date: Monday, 10 21, 2019; Speaker: See attached agenda; Building 10; Masur (10/21/19) and Lipsett (10/22/19)
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Wednesday, 10 23, 2019; Speaker: Joseph Zaia, Ph. D., Boston University; Building 50; 1227/1233; Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Thursday, 10 24, 2019; Speaker: Bruce Tromberg, NIBIB Director, NIBIB/ NIH; Dr. Susan Gregurick, Associate Director for Data Science, NIH; Building: Building 45 (Natcher Building); Videocast Event
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Thursday, 10 24, 2019; Speaker: Joachim Lingner, Ph.D., Full Professor for Life Sciences, EPF Lausanne (Swiss Federal Institute of Technology); Building: Building 37; Conference Room 6041/6107
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Monday, 10 28, 2019; Speaker: Xiangbo Ruan, Regulation of systemic lipid metabolism by human lncRNAs, The Cao group, CB, NHLBI; Ranganath Muniyappa, Hyperuricemia in insulin resistance, DEOB, NIDDK; Building: Building 10 (Clinical Center); Solarium Conference Room 9S233 (old Bunim Room)
Source: NIH Calendar of Events - Category: American Health Source Type: events
More News: Diets | Drugs & Pharmacology | Genetics | Nutrition | Study