Guidelines for evaluating myocardial cell death.

Guidelines for evaluating myocardial cell death. Am J Physiol Heart Circ Physiol. 2019 Aug 16;: Authors: Mishra PK, Adameová A, Hill JA, Baines CP, Kang PM, Downey J, Narula J, Takahashi M, Abbate A, Piristine HC, Kar S, Su S, Higa JK, Kawasaki NK, Matsui T Abstract Cell death is a fundamental process in cardiac pathologies. Recent studies revealed multiple forms of cell death, and several of them have been demonstrated to underlie adverse cardiac remodeling and heart failure. With the expansion in the area of myocardial cell death and increasing concerns over rigor and reproducibility, it is important and timely to set a guideline for the best practices of evaluating myocardial cell death. There are six major forms of regulated cell death observed in cardiac pathologies namely apoptosis, necroptosis, mitochondrial-mediated necrosis, pyroptosis, ferroptosis, and autophagic cell death. In this article, we described the best methods to identify, measure, and evaluate these modes of myocardial cell death. In addition, we discussed the limitations of currently practiced myocardial cell death mechanisms. PMID: 31418596 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research