Methods for Assessing Longitudinal Biomarkers of Time-to-Event Outcomes in CKD: A Simulation Study.

CONCLUSIONS: Different analytic methods resulted in markedly different results. Using the time-invariant average produces inaccurate association estimates, whereas other methods can estimate additive (cumulative average) or instantaneous (LOCF) associations depending on the hypothesized underlying association mechanism and research question.
PMID: 31416887 [PubMed - as supplied by publisher]

Source: Clinical Journal of the American Society of Nephrology : CJASN - August 14, 2019 Category: Urology & Nephrology Authors: Liu Q, Smith AR, Mariani LH, Nair V, Zee J Tags: Clin J Am Soc Nephrol Source Type: research