Co-infections of chickens with Avian Influenza Virus H9N2 and Moroccan Italy 02 Infectious Bronchitis Virus: effect on pathogenesis and protection conferred by different vaccination programs.

Co-infections of chickens with Avian Influenza Virus H9N2 and Moroccan Italy 02 Infectious Bronchitis Virus: effect on pathogenesis and protection conferred by different vaccination programs. Avian Pathol. 2019 Aug 15;:1-23 Authors: Belkasmi SFZ, Fellahi S, Touzani CD, Faraji FZ, Maaroufi I, Delverdier M, Guérin JL, Fihri OF, El Houadfi M, Ducatez MF Abstract Since the emergence of low pathogenic avian influenza (LPAI) H9N2 viruses in Morocco in 2016, severe respiratory problems have been encountered in the field. Infectious bronchitis virus (IBV) is often detected together with H9N2, suggesting disease exacerbation in cases of co-infections. This hypothesis was therefore tested and confirmed in laboratory conditions using specific pathogen free chickens. Most common field vaccine programs were then tested to compare their efficacies against these two co-infecting agents. IBV γCoV/chicken/Morocco/I38/2014 (Mor-IT02) and LPAI virus A/chicken/Morocco/SF1/2016 (Mor-H9N2) were thus inoculated to commercial chickens. We showed that vaccination with two heterologous IBV vaccines (H120 at day one and 4/91 at day 14 of age) reduced the severity of clinical signs as well as macroscopic lesions after experimental simultaneous challenge. In addition, LPAI H9N2 vaccination was more efficient at day 7 rather than at day 1 in limiting disease post simultaneous challenge. PMID: 31412705 [PubMed - as supplied by publisher]
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research