Acute flaccid myelitis and enterovirus D68: lessons from the past and present

Conclusion: This review presents the current knowledge on acute flaccid myelitis with respect to the clinical presentation and its differential diagnosis with Guillain-Barr é syndrome and acute transverse myelitis. We also discuss the association with enterovirus D68 and the presumed pathophysiological mechanism of this infection causing anterior horn cell damage. Sharing clinical knowledge and insights from basic research is needed to make progress in diagnosis, trea tment, and prevention of this new polio-like disease.What is Known:•Acute flaccid myelitis (AFM) is a polio-like condition characterized by rapid progressive asymmetric weakness, together with specific findings on MRI• AFM has been related to different viral agents, but recent outbreaks are predominantly associated with enterovirus D68.What is New:•Improving knowledge on AFM must increase early recognition and adequate diagnostic procedures by clinicians.• The increasing incidence of AFM urges cooperation between pediatricians, neurologists, and microbiologists for the development of treatment and preventive options.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research

Related Links:

Travel between New Zealand and some states of Australia possible before end of the year;first virus death among asylum seekers in Greece; Follow the latest updatesGlobal deaths pass 996,000India passes 6m casesRegular ‘circuit breaker’ lockdowns ‘could help control Covid’Boris Johnson faces revolt over forcing through Covid measuresSee all our coronavirus coverage5.19amBSTIndias confirmed coronavirus tally reached 6 million cases on Monday, keeping the country second to the United States in number of reported cases since the pandemic began, AP reports.The Health Ministry on Monday reported 82,170 ne...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Australia news UK news US news Science Infectious diseases Source Type: news
Titin related disorder is an emerging genetic disorder that is not well described. New phenotypes are being described with improvement in diagnostic genetic testing. We are presenting a 16-year-old Indian boy with congenital static myopathy, complete ophthalmoplegia, thoracolumbar scoliosis and obstructive sleep apnea. His investigations were significant for abnormal muscle magnetic resonance imaging with severe involvement of the gluteal, anterior compartment muscle and clear adductor sparing. His muscle biopsy of right vastus lateralis showed multi-minicores and distinctive cap-like structures.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
The degree of muscle replacement by fat, as determined from fat fraction (FF) maps using quantitative nuclear magnetic resonance imaging (NMRI), is a marker of ‘disease progression’ and has an integrative character. More predictive NMR biomarkers, reflecting rather the ‘disease activity’, such as water T2 and phosphorus (31P) NMR spectroscopy indices have proven their value in different neuromuscular disorders. Here, we investigated the correlation between the FF and FF changes over three years (ΔFF) and different 31P NMRS indices, including the level of phosphodiesters (PDE), normalized over ...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
In this study, we assesse d the fat fraction (FF) and fat fraction changes ΔFF over three years, as well as the correlation between water T2 and ΔFF, in 7 leg and 9 thigh muscles (and the weighted global values in leg and thigh), in 54 patients from the Jain Foundation's COS for dysferlinopathy from two different locations (Newcastle University and Institute of Myology, Paris) obtained annually over 3 years.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Myotonic dystrophy type 1 (DM1) is characterized by structural changes affecting skeletal muscle tissue, resulting in progressive muscle dysfunction and wasting. Quantitative biomarkers are needed to monitor disease progression and to assess treatment efficacy of upcoming innovative therapeutics. Magnetic resonance imaging (MRI) can provide useful insight for biomarkers since intramuscular fat fraction (FF), as measured by Dixon and water T2 (T2H2O) are considered efficient biomarkers of disease severity and disease activity of various neuromuscular diseases (NMDs) respectively.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
A recent study of rAAVrh.74.MHCK7.micro-dystrophin gene therapy was well tolerated and showed substantial micro-dystrophin expression and improvements in functional outcomes post-gene transfer. Quantitative magnetic resonance imaging and spectroscopy (qMRI/MRS) data were collected in three participants from that study (aged 5-7) and were compared with natural history qMRI/MRS data from a large ongoing study (n=180; n=54 age- and corticosteroid-status matched to gene therapy treated boys and 23 age-matched unaffected controls).
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
This blog is now closed. Follow the latest below:Coronavirus updates – live12.16amBSTWe ’ve launched a new blog at the link below – head there for the latest:Related:Coronavirus live news: global deaths near 1m as India poised to pass 6m cases11.50pmBSTHello,Helen Sullivan joining you now. I ’ll be bringing you the latest from around the world for the next few hours.Get in touch onTwitter @helenrsullivan.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak France UK news Europe Infectious diseases Science World news Saudi Arabia Japan South Korea Australia news Source Type: news
ConclusionsThere are many causes of cervical radiculopathy. Arterial tortuosity, a rare cause of radiculopathy, should be considered as a differential diagnosis. Consideration of the existence of this variation is of great importance in preventing possible dangerous complications during surgery.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Lack of clear rules about certification standards may be allowing manufacturers to sell tests based on poor or dodgy dataCoronavirus – latest updatesSee all our coronavirus coverageInadequate tests for Covid-19, based on poor or dodgy data, are proliferating in the UK because there are no clear rules on what companies have to prove before they can sell them, experts believe.The Royal Statistical Society (RSS)has set up a working group to investigate and draw up guidelines for the companies making the tests and those who assess them and buy them. The organisation says there are “concerns about a lack of basic st...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Medical research Science UK news Source Type: news
Carter Roberts’ motorized wheelchair didn’t arrive until the day he died. It had been a long time coming and his parents had fought hard to get it. The chair cost more than $32,000 and the insurance companies wouldn’t cover it, so the family went to court. One insurer eventually agreed to pay for some components of the chair but not the whole thing. And then none of it mattered anyway. On Sept. 22, 2018, the Roberts’ doorbell rang and the chair was delivered. Also on Sept. 22, 2018, Carter died, just three months shy of his sixth birthday. He had been largely paralyzed for the final two years of his...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Infectious Disease viruses Source Type: news
More News: Brain | Enterovirus | Guillain-Barr Syndrome | Lessons | Microbiology | MRI Scan | Neurology | Outbreaks | Pediatrics | Polio