Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function.

Genetic, epigenetic and biochemical regulation of succinate dehydrogenase function. Biol Chem. 2019 Aug 01;: Authors: Moosavi B, Zhu XL, Yang WC, Yang GF Abstract Succinate dehydrogenase (SDH), complex II or succinate:quinone oxidoreductase (SQR) is a crucial enzyme involved in both tricarboxylic acid cycle and oxidative phosphorylation, the two primary metabolic pathways for generating ATP. Impaired function of SDH results in deleterious disorders from cancer to neurodegeneration. SDH function is tailored in different cell types to meet the energy demands. Thus understanding how SDH function is regulated and how it operates in distinct cell types can support the development of therapeutic approaches against the diseases. In this article we discuss molecular pathways which regulate SDH function and describe extra roles played by SDH in specific cell types. PMID: 31408429 [PubMed - as supplied by publisher]
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research