Novel endoscopic treatment strategy for early esophageal cancer in cirrhotic patients with esophageal varices.

Novel endoscopic treatment strategy for early esophageal cancer in cirrhotic patients with esophageal varices. Oncol Lett. 2019 Sep;18(3):2560-2567 Authors: Xu ZG, Zhao YB, Yu J, Bai JY, Liu E, Tang B, Yang SM Abstract The safety and efficacy of endoscopic submucosal dissection (ESD) and radiofrequency ablation for early esophageal cancer (EEC) in cirrhotic patients has not been thoroughly investigated to date. The present study aimed to establish a standard treatment strategy for EEC in cirrhotic patients with esophageal varices. Six cirrhotic patients with early flat-type EECs (high-grade intraepithelial neoplasia) on or adjacent to esophageal varices were enrolled. Esophageal varix ligation (EVL) or transjugular intrahepatic portosystemic shunt (TIPS) were used for the initial management of esophageal varices. Follow-up endoscopy was performed two months following the initial procedure. The mean longitudinal length of the lesions was 4.3 cm (range, 2-6 cm). The average procedure time was 72.8 min (range, 34-135 min) and the average longitudinal length of the resected specimens was 45.6 mm (range, 30-90 mm). One case had a tumor-positive lateral margin with lymphovascular infiltration. Both complete and curative resection rates were 80% (4/5 lesions). Large intraoperative bleeding was detected in patients undergoing EVL compared with TIPS prior to the ESD procedure. No severe complications or mortality-associated events, including massive postoperative ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

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This study examines the extent to which data linkages between Indian Health Service, tribal data, and cancer registries affect cancer incidence rates among American Indians/Alaska Natives (AI/ANs) in Michigan. The incidence of tobacco- and alcohol-associated cancers for 1995-2012 was analyzed to compare rates of the Upper Peninsula (UP) and Lower Peninsula (LP) in Michigan and among AI/ANs and non-Hispanic Whites (NHWs). Complete linkage resulted in 1,352 additional AI/AN cases; 141 cases were linked via IHS records alone, while 373 were linked via tribal records alone; 838 were linked through both IHS and tribal records. ...
Source: Journal of Health Care for the Poor and Underserved - Category: International Medicine & Public Health Authors: Tags: J Health Care Poor Underserved Source Type: research
Abstract We conducted qualitative semi-structured telephone interviews with the directors of the 10 National Institutes of Health Centers for Population Health and Health Disparities (NIH/CPHHD) to identify factors that were associated with the sustainability of 19 interventions developed to address cancer disparities and 17 interventions developed to address cardiovascular disease disparities in the United States. Interview transcripts were analyzed using the constant comparative method of analysis to identify key themes and synthesize findings. Directors at NIH/CPHHD reported that barriers to sustainability incl...
Source: Journal of Health Care for the Poor and Underserved - Category: International Medicine & Public Health Authors: Tags: J Health Care Poor Underserved Source Type: research
ConclusionsUncommon Candida species frequently exhibit high rates of non-susceptibility to antifungals. Identification of all Candida isolates at the species level from blood samples is of value for treatment.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Ali Oubella, My Youssef Ait Itto, Aziz Auhmani, Abdelkhalek Riahi, Anthony Robert, Jean-Claude Daran, Hamid Morjani, Carol A. Parish, M'hamed EsseffarAbstractNew series of chiral isoxazoles and pyrazoles with monoterpenic skeleton, have been efficiently synthesized from naturally occurring (R)-Carvone, using 1,3-dipolar cycloaddition reaction with arylonitrile oxides and diarylnitrilimines. The reaction showed high peri-, and regioselectivity. In the case of diarylnitrilimines, the reaction revealed to be highly diastereoselecti...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 20 August 2019Source: Life SciencesAuthor(s): Madhulika Singh, Kulpreet Bhui, Richa Singh, Yogeshwer Shukla
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 15 November 2019Source: Carbohydrate Polymers, Volume 224Author(s): Vahid Hasantabar, Hamed Tashakkorian, Monire GolpourAbstractEfficient procedure for preparation of the novel magnetic nanobiocomposite (MNbC) was successfully established by employing click chemistry protocol. The resulted structure exhibited valuable characteristics from biological viewpoints. The prepared materials and obtained nanobiocomposite were characterized by means of nuclear magnetic resonance (NMR), fourier transform infrared (FT-IR), thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC). To assay the a...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
In this study, polydopamine (PDA) coated chitosan/calcium pyrophosphate hybrid microflowers (PDA@CS-CaP) were prepared using a facile approach and evaluated as a hemostatic agent. The surface morphology and elements, chemical groups, porous structure, thermostability, zeta potential, as well as surface wettability were systematically characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), N2 adsorption-desorption, thermogravimetry (TGA) and contact angle apparatus. Due to the synergistic effects of the high hydrophilicity (water contact an...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Few reports have investigated endoscopic submucosal tunnel dissection (ESTD) for superficial esophageal cancer in patients with liver cirrhosis due to the high bleeding risk. Based on propensity score analysis, this study reports the outcomes of ESTD for the treatment of esophageal cancer covering at least a semicircle of the esophageal lumen.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Saturday abstract Source Type: research
Conclusion: There are only a few treatment options available for patients with advanced HCC and severe liver damage. Multidisciplinary treatment such as locoregional treatments and prophylaxis of variceal bleeding may result in tumor downstaging, enabling radical liver transplantation without further exacerbation of liver damage.Case Rep Oncol 2019;12:289 –296
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionLymphovenous anastomosis was successfully implemented for the patient with esophagectomy, selected patients might benefit from this novel technique.
Source: World Journal of Surgery - Category: Surgery Source Type: research
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