Therapeutic Landscape of Metaplastic Breast Cancer

Metaplastic breast carcinoma (MPBC) represents 0.2-5% of all breast cancers and is typically very aggressive, with worse clinical outcomes than triple negative invasive breast cancers (TNBC)[1,2]. It is comprised of ductal, squamous, and/or chondroid, and spindle elements, with squamous cell carcinoma being the most frequent histological subtype. The World Health Organization (WHO) further divides metaplastic breast cancer into several subgroups: low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, squamous cell carcinoma, spindle cell carcinoma, metaplastic carcinoma with mesenchymal differentiation, mixed metaplastic carcinoma, and myoepithelial carcinoma[1].
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Tumour Review Source Type: research