Role of extracellular matrix remodeling gene SNPs in keratoconus.

Role of extracellular matrix remodeling gene SNPs in keratoconus. Br J Biomed Sci. 2019 Aug 09; Authors: Abdullah OA, El Gazzar WB, Salem TI, Al-Kamil EA Abstract Introduction: Single nucleotide polymorphisms (SNPs) in genes for certain structural components may be implicated in the pathogenesis of keratoconus. We hypothesised links between SNPs in genes coding for collagen, matrix metalloproteinase 9 (MMP9) and tissue inhibitor of matrix metalloproteinase (TIMP) and keratoconus. Furthermore, we hypothesised links between MMP-9 and TIMP-1 SNPs and their tear level in keratoconus patients. Materials and methods: We genotyped 200 keratoconus and 100 control subjects by allele specific PCR, and quantified MMP-9 &TIMP1 in tear samples by ELISA. Results: COL4A3 (rs55703767) and MMP-9 (rs17576) G alleles were over-represented in keratoconus patients (P
Source: British Journal of Biomedical Science - Category: Laboratory Medicine Tags: Br J Biomed Sci Source Type: research

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We present a series of three patients with previously undetected corneal pathology in grafted corneal tissue following keratoplasty for keratoconus. Postoperatively, a faint layer of anterior stromal haze involving the graft was observed in each patient upon slit lamp examination. Anterior segment optical coherence tomography (AS-OCT) confirmed the presence of anterior stromal scarring across the transplanted cornea. However, the ocular and systemic medical histories of the donors were unremarkable. As the suboptimal donor corneal tissue may escape the standard screening protocols, eye banks should consider adding AS-OCT i...
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Condition:   Keratoconus Interventions:   Procedure: After mechanical trephination, horizontal meridian of donor's cornea sutured to horizontal meridian of recipient cornea;   Procedure: : After mechanical trephination, horizontal meridian of donor's cornea sutured to vertical meridian of recipient cornea Sponsor:   Shahid Beheshti University of Medical Sciences Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Guests: Jessica B. Ciralsky, M.D. Associate Professor of Clinical Ophthalmology Weill Cornell Medical College, Cornell University New York William B. Trattler, M.D. Center For Excellence In Eye Care Miami
Source: As Seen From Here - Category: Opthalmology Authors: Source Type: podcasts
Conditions:   Retinitis Pigmentosa;   Maculopathy, Age Related;   Macular Dystrophy;   Macular Edema;   Retinal Detachment;   Retinal Degeneration;   Glaucoma;   Vascular Inflammation;   Hypertension;   Stroke;   Diabetes;   Corneal Dystrophy;   Keratoconus;   Dry Eye;   Trauma Interventions:   Device: High-resolution retinal imaging through adaptive optics;   Device: High-resolution retinal imaging through holographic systems Sponsor:   Centre Hospitalier National d'Ophtalmologie des ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: Improved topographic and biomechanic indexes at 1 year after CXL suggest it‘s potential as first-line therapy for RKC, as it is for KC.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
CONCLUSION: Due to the increased expression of NF-κB and iNOS, an inflammatory component in keratoconus must be assumed. The different regulation of the KC keratocytes by the iNOS inhibitor 1400W suggests an altered metabolic activity which can be caused by inflammatory processes. PMID: 31600816 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Abstract Floppy eyelid syndrome (FES) is defined as eyelid hyperlaxity with reactive palpebral conjunctivitis. It is a common condition that can be associated with significant ocular irritation. FES presents with easily everted eyelids and chronic papillary conjunctivitis in the upper eyelids. It is frequently associated with ocular and systemic diseases, notably keratoconus and obstructive sleep apnea, respectively. This comprehensive review describes the epidemiology, pathological changes, proposed pathogenesis, clinical manifestations, and a variety of treatment options for this condition. Conservative treatmen...
Source: The Ocular Surface - Category: Opthalmology Authors: Tags: Ocul Surf Source Type: research
Conclusion: Although KCN has been associated with LCA4, this type of LCA is typically moderate in severity and variable between patients. The present cases also have some systemic abnormalities. PMID: 31576779 [PubMed - in process]
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
Purpose of review To summarize the ocular and systemic associations of floppy eyelid syndrome (FES) as well as provide an up-to-date review on the pathogenesis and treatment strategies. Recent findings Virtually all patients with FES have obstructive sleep apnea (OSA). However, a significantly lower proportion of patients with OSA have FES. Although some studies demonstrate no association between OSA and FES, almost all show at least an association with increased eyelid laxity, which may be a less severe form of FES. FES has also been associated with keratoconus (KCN) and glaucoma. Decreased corneal hysteresis has bee...
Source: Current Opinion in Ophthalmology - Category: Opthalmology Tags: OCULAR MANIFESTATIONS OF SYSTEMIC DISEASE: Edited by John A. Gonzales Source Type: research
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