Cardiotoxicity of Cancer Therapies

Cardiotoxicity is a known complication of many cancer therapies. While the cardiotoxicity of established agents such as anthracyclines, antimetabolites, and alkylating agents is well known, it is important to realize that newer anticancer therapies such as tyrosine kinase inhibitors, angiogenesis inhibitors, and checkpoint inhibitors are also associated with significant adverse cardiovascular effects. Echocardiography, magnetic resonance imaging, and radionuclide imaging have been used to identify these complications early and prevent further consequences. We will discuss the different classes of cancer therapeutic agents that cause cardiotoxicity, the mechanisms that lead to these effects, and strategies that can be used to prevent the cardiac morbidity and mortality associated with their use.
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research

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Abstract Magnetic hyperthermia therapy (MHT) and chemodynamic therapy (CDT) are non-invasive in situ treatments without depth limitations and with minimum adverse effects on surrounding healthy tissue. We herein report a mitochondria-targeting magnetothermogenic nanozyme (Ir@MnFe2O4 NPs) for highly efficient cancer therapy. An iridium(III) complex (Ir) acts as a mitochondria-targeting agent on the surface of MnFe2O4 NPs. On exposure to an alternating magnetic field (AMF), the Ir@MnFe2O4 NPs induce a localized increase in temperature causing mitochondrial damage (MHT effect). Meanwhile glutathione (GSH) reduces Fe(...
Source: Biomaterials - Category: Materials Science Authors: Tags: Biomaterials Source Type: research
Analyst, 2020, Advance Article DOI: 10.1039/D0AN00267D, PaperWentao Wang, Qicheng Zhang, Ming Zhang, Yihan Liu, Jian Shen, Ninglin Zhou, Xiaoyuan Lu, Changhong Zhao In recent years, carbon dots (CDs) with red-emitting wavelengths have received increasing attention in cancer therapy and imaging. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Abstract Magnetic resonance imaging (MRI) is an important imaging modality for clinical disease diagnosis, and nearly 50% of clinical MRI examinations require contrast agents to enhance the diagnostic sensitivity. This review provides a summary of the major MRI contrast agents and their classification, and the advantages and limits of the commercially available MRI contrast agents, and elaborates on the exceedingly small magnetic iron oxide nanoparticles (ES-MIONs), dotted core-shell iron and gadolinium hybrid nanoparticles (FeGd-HN) and exceedingly small gadolinium oxide nanoparticles (ES-GON). These nanoparticle...
Source: Journal of Southern Medical University - Category: Universities & Medical Training Authors: Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
Immune checkpoint inhibitors (ICIs) are emerging as a new treatment option for cancer therapy[1]. Unlike conventional cytotoxic chemotherapy, ICI does not cause cancer cell death directly, but rather alters cancer immunity and the tumor microenvironment [1 –4]. With the increasingly widespread use of ICIs, an issue has emerged; namely, that conventional response criteria based on tumor size may not be adequate for evaluating anti-tumor activity and long-term efficacy of ICIs [5,6]. Compared with chemotherapy, ICIs achieve modest or sometimes no sign ificant improvement in tumor response as assessed according to the R...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging. Wnt/β-Catenin Signaling as a Point of Intervention to Spur Greater Neural Regeneration https://www.fightaging.org/archives/2020/02/wnt-%ce%b2-catenin-sig...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study suggests that FCF NPs may be safely used in cancer therapy via PDT and could be a versatile therapeutic tool and biocompatible theragnostic agent, which may be used in diagnostic imaging.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conditions:   Cardiotoxicity;   Pediatric Cancer;   Heart Failure Interventions:   Diagnostic Test: Cardiac magnetic resonance imaging (MRI);   Diagnostic Test: Echocardiography;   Diagnostic Test: Electrocardiogram Sponsor:   University of California, San Diego Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 18 January 2020Source: Materials LettersAuthor(s): Meng Luo, Lingling Xu, Jiale Xia, Hongyang Zhao, Yaping Du, Bo LeiAbstractPorous nanomaterials have great potential in biomedical applications due to their unique structure and properties. Herein, we demonstrated the synthesis of porous gadolinium oxide nanosheets (Gd2O3 NSs) with a colloidal synthesis method. The porous Gd2O3 NSs exhibited a promising pH-responsive drug release behavior for cancer chemotherapy and can be used as an efficient contrast agent for magnetic resonance (MR) imaging.
Source: Materials Letters - Category: Materials Science Source Type: research
v Felix N. Tomilin Vladimir N. Zabluda Yulia Alekhina Kirill A. Lukyanenko Yury E. Glazyrin Valery A. Svetlichnyi Maxim V. Berezovski Anna S. Kichkailo Nanotechnologies involving physical methods of tumor destruction using functional oligonucleotides are promising for targeted cancer therapy. Our study presents magnetodynamic therapy for selective elimination of tumor cells in vivo using DNA aptamer-functionalized magnetic nanoparticles exposed to a low frequency alternating magnetic field. We developed an enhanced targeting approach of cancer cells with aptamers and arabinogalactan. Aptamers to fibrone...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Publication date: April 2020Source: Materials Science and Engineering: C, Volume 109Author(s): Emilia Piosik, Paweł Klimczak, Marta Ziegler-Borowska, Dorota Chełminiak-Dudkiewicz, Tomasz MartyńskiAbstractMagnetite nanoparticles are promising materials for application in magnetic resonance imaging, targeted drug delivery, enzyme immobilization and cancer therapies based on hyperthermia thanks to their biocompatibility, wide chemical affinity and superparamagnetic properties. However, there is still the lack of the knowledge of interactions between magnetite nanoparticles covered with the bioactive polymers and biological...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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