Enhancement of chemosensitivity by WEE1 inhibition in EGFR-TKIs resistant non-small cell lung cancer.

This study revealed that WEE1 expression was increased after EGFR-TKIs resistance, and WEE1 knockdown could enhance chemosensitivity in EGFR-TKIs resistant NSCLC. It is suggested the combination of WEE1 inhibitor and chemotherapy might improve the clinical outcome of NSCLC patients with acquired EGFR-TKIs resistance.
PMID: 31387179 [PubMed - in process]

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 9, 2019 Category: Drugs & Pharmacology Authors: Liu D, Cao Z, Xu W, Lin G, Zhou X, Ding X, Wang N, Wu C, Su B Tags: Biomed Pharmacother Source Type: research