Involvement of H+-gradient dependent transporter in PGE2 release from A549 cells

Prostaglandins (PGs) are lipid mediators synthesized from 20-carbon essential fatty acids such as arachidonic acid (AA) [1,2]. PGs produced in the intracellular space are released and bind their specific receptors on the cell surface to exert their biological effects [3]. Among them, PGE2 is a predominant product and exerts diverse biological effects by binding to specific receptors (EP1 - EP4) [4] Moreover, PGE2 is associated with several diseases such as inflammation, cancer, and cardiovascular diseases [5 –8], such that EP receptors and PGE synthase could serve as therapeutic targets for drug discovery [9–12].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research