A single day of high fat diet feeding induces lipid accumulation and insulin resistance in brown adipose tissue in mice.

In conclusion, we showed that a single day of HFD feeding is sufficient to induce the first signs of whitening and insulin resistance in BAT, which reduces the uptake of glucose and triglyceride-derived fatty acids. BAT whitening and insulin resistance is likely sustained by reduced mitochondrial oxidation due to changes in mitochondrial dynamics and macrophage infiltration, respectively. Likely, the switch to HFD swiftly induces thermogenesis in other metabolic organs, which allows attenuation of BAT thermogenesis. PMID: 31386566 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31386566?dopt=Abstract

Source: Am J Physiol Endocri... - August 5, 2019 Category: Endocrinology Authors: Kuipers EN, Held NM, In Het Panhuis W, Modder M, Ruppert PMM, Kersten S, Kooijman S, Guigas B, Houtkooper RH, Rensen PCN, Boon MR Tags: Am J Physiol Endocrinol Metab Source Type: research