Optimising clonidine dosage for sedation in mechanically ventilated children: a pharmacokinetic simulation study.

CONCLUSIONS: The variety of dosage regimens in previous studies of clonidine along with difficulties in the conduct of interventional studies may have contributed to the lack of efficacy data to support its use. Simulations of clonidine plasma concentrations based on known population pharmacokinetic parameters suggest a loading dose followed by higher than current practice maintenance dose infusion is required to achieve adequate steady-state concentrations early in treatment. Further PKPD studies will aid in the determination of the optimal clonidine dosage regimen. This article is protected by copyright. All rights reserved.
PMID: 31373752 [PubMed - as supplied by publisher]

Source: Paediatric Anaesthesia - August 1, 2019 Category: Anesthesiology Authors: Hayden JC, Bardol M, Doherty DR, Dawkins I, Healy M, Breatnach CV, Gallagher PJ, Cousins G, Standing JF Tags: Paediatr Anaesth Source Type: research