IL12 and IFN γ secretion by donor mononuclear cells in response to host antigens may predict acute GVHD after HSCT.

In conclusion, IL12 and IFNγ of donors' origin not of patients' origin may predict the occurrence of acute GVHD. The MLC model may allow prediction of acute GVHD upfront before conditioning of the patient or mobilization of the donor.
PMID: 31375357 [PubMed - as supplied by publisher]

Source: Immunobiology - July 19, 2019 Category: Allergy & Immunology Authors: Kamel AM, Elsharkawy NM, Abdelfattah EK, Abdelfattah R, Samra MA, Wallace P, Mahmoud HK Tags: Immunobiology Source Type: research