Comparison of in vivo activity of garenoxacin and levofloxacin in a murine pneumonia mixed-infection model by Streptococcus pneumoniae and Parvimonas micra.
Comparison of in vivo activity of garenoxacin and levofloxacin in a murine pneumonia mixed-infection model by Streptococcus pneumoniae and Parvimonas micra. Jpn J Infect Dis. 2019 Jul 31;: Authors: Kato H, Hagihara M, Yokoyama Y, Suematsu H, Asai N, Koizumi Y, Yamagishi Y, Mikamo H Abstract Community-acquired pneumonia (CAP) can involve mixed-infection. However, there are few studies investigating its antimicrobial activity in mixed-infection. The aim of this study was to compare the in vivo antimicrobial activity of GRNX and levofloxacin (LVFX) against Streptococcus pneumoniae and Parvimonas micra in a murine pneumonia mixed-infection model. S. pneumoniae D-6888 and P. micra No. 242 were used in this study. Antimicrobial activity was calculated for each isolate as the change in bacterial count of lungs (Δlog10 CFU/mL) obtained in the treated mice after 24 h compared with the count in the starting control animals (0 h). The MICs of GRNX and LVFX against S. pneumoniae D-6888 were 0.06 and 0.5 mg/L. The MICs of these quinolones against P. micra No. 242 were 0.03 and 0.12 mg/L. In a murine pneumonia mixed-infection model, GRNX showed significantly higher in vivo antimicrobial activity against S. pneumoniae than LVFX (GRNX; -2.02 ± 0.99 log10 CFU/mL vs. LVFX; -0.97 ± 0.61 log10 CFU/mL, p = 0.0188). Numerically better activity against P. micra was noted for GRNX therapy in this model (GRNX; -1.12 ± 0.56 log10 CFU/mL vs. LVFX; -0.61 ...
A recap of Tuesday’s top stories: Pneumonia number one killer of children; Australia’s wildfires rage on; Ebola vaccine gets green light; new child labour and trafficking study; Malnutrition soars in Latin America and Caribbean; Intellectual Property chief encourages innovation.
In conclusion, we emphasize that it is of importance to work closely with the hospital administration to take measures and that necessary assistance is provided. PMID: 31709934 [PubMed - in process]
CONCLUSION: This study identified prior antibiotic exposure, recent surgery and the use of invasive procedures as significant risk factors for colonization or infection with CRE. Also, the need for public awareness, continuing education for healthcare professionals, optimum use of invasive devices, enhanced surveillance, and antimicrobial stewardship are highlighted here which can limit CRE transmission in healthcare facilities. PMID: 31707406 [PubMed - in process]
Pneumonia, an entirely preventable disease, kills more children than any other illness in the world, one child every 39 seconds. But although that statistic is well known, funding to improve survival rates continues to come up short, the UN and partners warned on Tuesday, World Pneumonia Day.
By Alice Rwema Iribagiza, Communications Officer, Ingobyi Nurse Esther at work. Photo credit: IntraHealth International.November 12, 2019Esther Mukahabiyambere is one of 326 district-based mentors trained on the Integrated Management of Childhood Illness (IMCI) approach. Through the USAID-fundedIngobyi Activity, health workers are using IMCI in Rwanda to prevent and treat pneumonia, diarrhea, malnutrition, and malaria. The project equips health care providers with clinical knowledge, skills, and attitudes to improve the quality of care, helping the government of Rwanda reduce child mortality, particularly the managemen...
[Daily Trust] The death of 162,000 Nigerian children, of pneumonia in 2018, is the highest of the estimated total of 802,000 pneumonia deaths globally, the Save the Children said this in Abuja.
[This Day] Abuja -A leading child rights organisation, Save the Children, has revealed that pneumonia claimed the lives of 162,000 children below the age of five in Nigeria in 2018.
[Vanguard] A new report by the United Nations Children Fund (UNICEF) shows Nigeria recorded the highest global deaths from pneumonia at 162,000 last year.
(Murdoch Childrens Research Institute) A new study has found severe pneumonia decreases by 35 per cent in children who receive a vaccine against a pneumonia-causing bacteria.
Emergency admissions have risen more than 50 per cent over the last decade, with 56,000 British children hospitalised with the condition last year.