Front Cover: Proteome Profile of Endogenous Retrotransposon ‐Associated Complexes in Human Embryonic Stem Cells

DOI:10.1002/pmic.201900169Long Interspersed Element ‐1 (L1) is a major transposable element present in the human genome. L1 activity is implicated in various human diseases and cancer. Depicted here is a colony of human embryonic stem cell (ESCs) expressing the endogenous L1‐encoded ORF1 protein. ORF1p appears as distinct cytoplasmic foci (green) close to nuclei expressing the stem cell marker, OCT4 (red). Phalloidin‐Cyan (blue) stains actin. In article numberhttps://doi.org/10.1002/pmic.2019001691900169, Vuong et al. identify cellular proteins associated with ORF1p in human ESCs. Understanding ORF1p function is likely critical to deciphering how the L1 element has evolved with our species and impacts our biology and physiology.
Source: Proteomics - Category: Biochemistry Authors: Tags: Front Cover Source Type: research