Potential Drug Targets against Hepatitis B Virus Based on Both Virus and Host Factors.
CONCLUSION: Since HBV is obligate intracellular parasite, and as such it depends on host cellular components and functions to replicate itself. The targeting both virus and host might be a novel therapeutic option for hepatitis B. Accordingly, we analyse the advances in the study of the potential drug targets for anti-HBV infection, focusing on targeting virus genome, on targeting host cellular functions and on targeting virus-host proteins interactions, respectively. Meanwhile, the immune targets against chronic hepatitis B are also emphasized. In short, the review provides a summary of antiviral therapeutic strategies to target virus factors, host factors and immune factors for future designing of the anti-HBV innovative drug.
PMID: 31362671 [PubMed - as supplied by publisher]
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Zhang BY, Chai DP, Wu YH, Qiu LP, Zhang YY, Ye ZH, Yu XP Tags: Curr Drug Targets Source Type: research
More News: Drugs & Pharmacology | Epidemics | Epidemiology | Hepatitis | Hepatitis B | Hepatitis Vaccine | Parasitic Diseases | Parasitology | Study | Vaccines