Lung damage following whole body, but not intramuscular, exposure to median lethality dose of sarin: findings in rats and guinea pigs.

Conclusions: These data clearly point out the importance of using the appropriate route of administration in studying the deleterious effects of volatile nerve agents, as well as the selection of the appropriate animal species. Since airways form major target organs for the development of injury following inhalation toxicity, they should be included in any comprehensive evaluation of countermeasures efficacy. PMID: 31359796 [PubMed - as supplied by publisher]
Source: Inhalation Toxicology - Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research