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Patients with inflammatory bowel disease (IBD) have heightened risk of colorectal cancer (CRC) and poor compliance with surveillance colonoscopy. DNA methylation is broadly informative for CRC in the general population1 and Lynch syndrome.2 We recently reported that stool assay of methylated BMP3 and VAV3, both normalized by methylated ZDHHC1, were highly discriminate for the combined endpoint of high-grade dysplasia and CRC in patients with IBD. In their recent letter, Peppelenbosch et  al highlight that a target of the VAV3 protein, p21RAC, can be inactivated by thiopurine therapy.

Source: Clinical Gastroenterology and Hepatology - July 3, 2019 Category: Gastroenterology Authors: John B. Kisiel, Douglas W. Mahoney, William R. Taylor, Paquale Klepp Tags: Letter to the Editor Source Type: research