Sexual dimorphism in hypothalamic inflammation in the offspring of dams exposed to diet rich in high fat and branched chain amino acids.

In this study, we exposed pregnant and lactating C57BL/6JB female mice to either HFD, HFD with supplemented BCAA (HFD+BCAA), or standard chow (SC) diets, and studied offspring metabolic phenotypes. Both maternal HFD and HFD supplemented with BCAA had similar effect rendered the offspring metabolic imbalance and impaired their ability to cope with HFD when challenged during aging. The metabolic effects of HFD challenge were more profound in females, worsening female offspring ability to cope with an HFD challenge by activating hypothalamic inflammation in aging. Moreover, the sex differences in hypothalamic ER-α expression levels were lost in female offspring upon HFD challenge, supporting a link between ER-α levels and hypothalamic inflammation in offspring and highlighting the programming potential of hypothalamic inflammatory responses and maternal nutrition. PMID: 31361548 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research