Brain-derived neurotrophic factor (BDNF) and TrkB hippocampal gene expression are putative predictors of neuritic plaque and neurofibrillary tangle pathology.

DISCUSSION: Results indicate that BDNF and TrkB dysregulation contribute to AD neuropathology, most notably hippocampal NPs and NFTs. These data suggest attenuating BDNF/TrkB signaling deficits either at the level of BDNF, TrkB, or downstream of TrkB signaling may abrogate NPs and/or NFTs. PMID: 31349032 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31349032?dopt=Abstract

Source: Neurobiology of Disease - July 22, 2019 Category: Neurology Authors: Ginsberg SD, Malek-Ahmadi MH, Alldred MJ, Chen Y, Chen K, Chao MV, Counts SE, Mufson EJ Tags: Neurobiol Dis Source Type: research