Nigrostriatal Dopaminergic Dysfunction and Altered Functional Connectivity in REM Sleep Behavior Disorder With Mild Motor Impairment

Rapid eye movement sleep behavior disorder is a parasomnia characterized by symptoms of dream enactment and loss of muscle atonia during rapid eye movement sleep. Mild motor impairment is present in some patients with rapid eye movement sleep behavior disorder and it is presumed to be a risk factor for conversion to synucleinopathies. The purpose of this study was to identify patients with mild motor impairment by evaluating finger tapping and to investigate its pathophysiology. Twenty-three patients with rapid eye movement sleep behavior disorder and 20 healthy control subjects were recruited in this study. We accurately evaluated finger tapping including amplitude and peak open and close speeds with a magnetic sensing device and identified patients with mild motor impairment. Moreover, we performed 123I-2β-carbomethoxy-3β-(4-iodophenyl) nortropane single-photon emission computed tomography and resting-state functional magnetic resonance imaging. 123I-2β-carbomethoxy-3β-(4-iodophenyl) nortropane uptake for the bilateral caudate, anterior putamen, and posterior putamen was calculated, and the resting-state functional connectivity of the sensorimotor network was analyzed. Using finger tapping parameters, we identified eight patients with mild motor impairment. In patients with mild motor impairment, all finger tapping parameters were significantly impaired compared to those in patients with normal motor function, while there were no significant differences ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

Related Links:

BILLY CONNOLLY, best known for his stand-up comedy acts, revealed he was being treated for Parkinson ’s disease back in 2013. Earlier this year he disclosed its advance may force his retirement from performing, and more recently he revealed how the condition has started affecting his sleep.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusions: EDS did not worsen over 10 years, although other PD aspects did. EDS in PD seems to be a complex nonmotor symptom that is unrelated to deterioration of motor symptoms in PD. PMID: 31583073 [PubMed]
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Source: International Journal of Neuroscience - Category: Neuroscience Authors: Source Type: research
In conclusion, older adults exhibited decreased markers of UPR activation and reduced coordination with autophagy and SC-associated gene transcripts following a single bout of unaccustomed resistance exercise. In contrast, young adults demonstrated strong coordination between UPR genes and key regulatory gene transcripts associated with autophagy and SC differentiation in skeletal muscle post-exercise. Taken together, the present findings suggest a potential age-related impairment in the post-exercise transcriptional response that supports activation of the UPR and coordination with other exercise responsive pathways (i.e....
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
SNCA gene copy number gain has been reported as a genetic cause for autosomal dominant Parkinson's disease (PD) [1], but it has not been described in Chinese patients. We identified two PD families (Fig. 1A and B) with SNCA duplications (1.04%) among 193 Chinese patients with familial PD: a 139kb duplication in family A and a 5.4Mb duplication in family B (Fig. 1C). The 139kb duplication is the smallest one so far reported [2]. The two index patients shared many clinical phenotypes including a positive family history, bradykinesia and rigidity, and non-motor symptoms such as REM sleep behavior disturbance (RBD), anosmia, c...
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
Conclusion: The PD patients showed a high prevalence of OSA, with the supine position exerting a significant influence on the OSA in these patients, and some factors that are associated with OSA in the general population did not seem to have a greater impact on PD patients.RESUMO A Apneia Obstrutiva do Sono (AOS) chega a acometer at é 66% dos pacientes com doença de Parkinson (DP), prevalência maior, portanto, que a da população geral. Embora seja mais prevalente, a relação entre AOS e DP permanence controversa, com trabalhos confirmando e outros afastando a relaç&atil...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
CONCLUSION: Disturbances in sleep architecture are associated with higher UPDRS scores and worse prognosis at 1st and 3rd post-operative years. Similar results obtained while stimulator was OFF at the end of 1st year support the presence of microlesion effect after STN DBS, which is probably not long lasting. PMID: 31521396 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Dijkstra and collaborators provide interesting and important issue in clinical research addressing REM sleep without atonia as a possible prodromal marker for Lewy body disease, an early finding in Parkinson's disease. Though prodromal studies are relevant, it is also mandatory to consider the causes of mortality of Parkinson's disease once it is stablished, such as Sudden Unexpected Death in Parkinson's Disease.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
Conclusions:ID comorbid to PD is associated with the classic psychological factors perpetuating ID in neurological disease-free individuals with insomnia. Target-oriented interventions for instance cognitive behavioral therapy for chronic insomnia should be considered as a treatment approach for ID comorbid to PD.Citation:Lebrun C, Gély-Nargeot M-C, Maudarbocus KH, Rossignol A, Geny C, Bayard S. Presleep cognitive arousal and insomnia comorbid to parkinson disease: evidence for a serial mediation model of sleep-related safety behaviors and dysfunctional beliefs about sleep.J Clin Sleep Med. 2019;15(9):1217–1224.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Publication date: Available online 10 September 2019Source: The Lancet NeurologyAuthor(s): John-Paul Taylor, Ian G McKeith, David J Burn, Brad F Boeve, Daniel Weintraub, Claire Bamford, Louise M Allan, Alan J Thomas, John T O'BrienSummaryDementia with Lewy bodies and Parkinson's disease dementia, jointly known as Lewy body dementia, are common neurodegenerative conditions. Patients with Lewy body dementia present with a wide range of cognitive, neuropsychiatric, sleep, motor, and autonomic symptoms. Presentation varies between patients and can vary over time within an individual. Treatments can address one symptom but wors...
Source: The Lancet Neurology - Category: Neurology Source Type: research
More News: Brain | CT Scan | MRI Scan | Neurology | Parkinson's Disease | Sleep Disorders | Sleep Medicine | SPECT | Study