Epidemiologic Trends, Global Shifts in Meningococcal Vaccination Guidelines, and Data Supporting the Use of MenACWY-TT Vaccine: A Review

AbstractNeisseria meningitidis is a major cause of meningitis and septicemia with cases, outbreaks, and epidemics reported globally in industrialized and non-industrialized countries.N. meningitidis is categorized into 12 serogroups; however, only 5 serogroups (A, B, C, W, Y) are responsible for the majority of disease. Invasive meningococcal disease (IMD) occurs unpredictably; protection is therefore best achieved by initiating proactive vaccination strategies. Vaccines are currently available for the five main disease-causing serogroups. With the evolution of meningococcal vaccines and changes in IMD epidemiology, different vaccination strategies have been used. Recently, the rapid clonal expansion of meningococcal serogroup W (MenW) has been associated with a change in the national and regional vaccination recommendations from monovalent meningococcal serogroup C vaccines to meningococcal serogroup A, C, W, Y (MenACWY) vaccines in several countries. This review highlights these and other changes in IMD epidemiology and meningococcal vaccination recommendations, summarizes information available for currently available conjugate MenACWY vaccines, and focuses on clinical study data for the most recently approved MenACWY conjugate vaccine, MenACWY vaccine conjugated to tetanus toxoid (MenACWY-TT). MenACWY-TT studies spanned multiple age groups and generally demonstrated safety and immunogenicity in comparison with other meningococcal vaccines and under concomitant administrati...
Source: Infectious Diseases and Therapy - Category: Infectious Diseases Source Type: research

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Source: Journal of Food Engineering - Category: Food Science Source Type: research
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Source: Journal of Theoretical Biology - Category: Biology Source Type: research
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Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
Condition:   Meningitis, Bacterial Intervention:   Biological: Lyophilised Neisseria lactamica Sponsors:   University of Southampton;   University Hospital Southampton NHS Foundation Trust Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Substance Use;   HIV Infections;   HCV Infection;   Sexually Transmitted Infections (Not HIV or Hepatitis);   Overdose, Drug;   Opioid Use Interventions:   Behavioral: Re-entry Health Linkage;   Behavioral: Overdose Education Sponsors:   University of Kentucky;   National Institute on Drug Abuse (NIDA);   Substance Abuse and Mental Health Services Administration (SAMHSA);   Emory University;   Temple University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: PLOS Currents Disasters - Category: International Medicine & Public Health Authors: Source Type: research
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