The approximate formulas predicting personal somatic telomere length using patient blood test data.

This study analyzed the correlation between telomere length in peripheral leukocytes and laboratory data to select test items relating closely to biological aging. We established formulas from these clinical data to predict the personal telomere length. The subjects were patients having visited Kyushu University Beppu Hospital from 2012 to 2015. Two hundred thirty-two patients were enrolled. The blood data were collected and telomere lengths were measured by Southern blotting method. The patients showed significant correlations between the telomere length and several blood test data with a gender-related difference. Candidate formulas are as follows; Predicted telomere length (kb) for men = 8.59 - 0.037 x Age (years) + 0.024 x Hemoglobin (g/dL) Predicted telomere length (kb) for women = 4.83 - 0.019 x Age (years) + 0.23 x Albumin (g/dL) + 0.0001 x White Blood Cells (/mm3) +0.0020 x Red Blood Cells (x 104/mm3) + 0.0032 x Total Cholesterol (mg/dL) Thus the derived formulae allow for the accurate differential prediction of telomeric length in male and female patients. PMID: 31340127 [PubMed - as supplied by publisher]
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research