Proliferative actinic keratosis: An invasive squamous cell carcinoma or not?

In conclusion, 25% (13/51) of lesions diagnosed as PAK were invasive SCC, which is of clinical and histopathological significance. Our results suggest that the definition of PAK should be histopathologically revised and that total excisional biopsy instead of punch biopsy should be considered, especially for lesions with a proliferative appearance. 
Source: Acta Dermatovenerologica Croatica - Category: Dermatology Source Type: research