Efficient T cell-B cell collaboration guides autoantibody epitope bias and onset of celiac disease [Immunology and Inflammation]

B cells play important roles in autoimmune diseases through autoantibody production, cytokine secretion, or antigen presentation to T cells. In most cases, the contribution of B cells as antigen-presenting cells is not well understood. We have studied the autoantibody response against the enzyme transglutaminase 2 (TG2) in celiac disease patients...

Source: Proceedings of the National Academy of Sciences - July 22, 2019 Category: Science Authors: Rasmus Iversen, Bishnudeo Roy, Jorunn Stamnaes, Lene S. Hoydahl, Kathrin Hnida, Ralf S. Neumann, Ilma R. Korponay–Szabo, Knut E. A. Lundin, Ludvig M. Sollid Tags: Biological Sciences Source Type: research