Quantitative modelling predicts the impact of DNA methylation on RNA polymerase II traffic [Biophysics and Computational Biology]

Patterns of gene expression are primarily determined by proteins that locally enhance or repress transcription. While many transcription factors target a restricted number of genes, others appear to modulate transcription levels globally. An example is MeCP2, an abundant methylated-DNA binding protein that is mutated in the neurological disorder Rett syndrome....

Source: Proceedings of the National Academy of Sciences - July 22, 2019 Category: Science Authors: Justyna Cholewa-Waclaw, Ruth Shah, Shaun Webb, Kashyap Chhatbar, Bernard Ramsahoye, Oliver Pusch, Miao Yu, Philip Greulich, Bartlomiej Waclaw, Adrian P. Bird Tags: Biological Sciences Source Type: research