The natural history of milk allergy in an observational cohort
Objective: There are few studies on the natural history of milk allergy. Most are single-site and not longitudinal, and these have not identified a means for early prediction of outcomes.Methods: Children aged 3 to 15 months were enrolled in an observational study with either (1) a convincing history of egg allergy, milk allergy, or both with a positive skin prick test (SPT) response to the trigger food and/or (2) moderate-to-severe atopic dermatitis (AD) and a positive SPT response to milk or egg. Children enrolled with a clinical history of milk allergy were followed longitudinally, and resolution was established by means of successful ingestion.Results: The cohort consists of 293 children, of whom 244 were given a diagnosis of milk allergy at baseline. Milk allergy has resolved in 154 (52.6%) subjects at a median age of 63 months and a median age at last follow-up of 66 months. Baseline characteristics that were most predictive of resolution included milk-specific IgE level, milk SPT wheal size, and AD severity (all P
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Robert A. Wood, Scott H. Sicherer, Brian P. Vickery, Stacie M. Jones, Andrew H. Liu, David M. Fleischer, Alice K. Henning, Lloyd Mayer, A. Wesley Burks, Alexander Grishin, Donald Stablein, Hugh A. Sampson Tags: Food, drug, insect sting allergy, and anaphylaxis Source Type: research
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