Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations

Publication date: Available online 17 July 2019Source: The Lancet Respiratory MedicineAuthor(s): Juncheng Dai, Jun Lv, Meng Zhu, Yuzhuo Wang, Na Qin, Hongxia Ma, Yong-Qiao He, Ruoxin Zhang, Wen Tan, Jingyi Fan, Tianpei Wang, Hong Zheng, Qi Sun, Lijuan Wang, Mingtao Huang, Zijun Ge, Canqing Yu, Yu Guo, Tong-Min Wang, Jie WangSummaryBackgroundGenetic variation has an important role in the development of non-small-cell lung cancer (NSCLC). However, genetic factors for lung cancer have not been fully identified, especially in Chinese populations, which limits the use of existing polygenic risk scores (PRS) to identify subpopulations at high risk of lung cancer for prevention. We therefore aimed to identify novel loci associated with NSCLC risk, and generate a PRS and evaluate its utility and effectiveness in the prediction of lung cancer risk in Chinese populations.MethodsTo systematically identify genetic variants for NSCLC risk, we newly genotyped 19 546 samples from Chinese NSCLC cases and controls from the Nanjing Medical University Global Screening Array Project and did a meta-analysis of genome-wide association studies (GWASs) of 27 120 individuals with NSCLC and 27 355 without NSCLC (13 327 cases and 13 328 controls of Chinese descent as well as 13 793 cases and 14 027 controls of European descent). We then built a PRS for Chinese populations from all reported single-nucleotide polymorphisms that have been reported to be associated with lung cancer risk at ge...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research